In mixing bowl, combine ground turkey, tofu, cumin, and garlic. Mix well. Form two patties.
Heat oven-proof skillet over medium. Mist both sides of each burger with cooking spray. Cook 3-1/2 minutes per side.
Transfer skillet to oven and bake 5-7 minutes or until internal temperature reaches 165F.
Let stand 5 minutes to cool slightly. Place each burger on 2 pieces of lettuce. Garnish each burger with 1 tablespoon salsa, 1 tablespoon of sour cream, and three slices of avocado. Top with remaining lettuce leaves.