Line a cookie sheet with foil and coat with fat-free cooking spray.
Mix together in a large shallow bowl, the bread crumbs, Cajun or Creole seasoning chili powder, and ground red pepper.
Coat the catfish nuggets with cooking spray. Dip the nuggets in bread-crumb mixture, rolling to coat completely.
Preheat the cookie sheet in the oven until smoking hot (2 to 3 minutes). Place the nuggets on the hot cookie sheet, coat the tops with fat-free cooking spray and bake until just opaque throughout, about 12 minutes.
Serve drizzled with hot pepper sauce and with the lemon wedges for squeezing.