Clinical Trials Want Ads

Type 1 Specific
Type 2 Specific
Gastroparesis
Neuropathy Trials
Pediatric Diabetes Specific
Not Diabetes Specific

Type 1 Specific

WANTED:

Title: PERL: a multicenter trial of allopurinol to prevent renal function (GFR) loss in type 1 diabetes s

The goal of this study is to investigate whether a medication called allopurinol may help prevent the loss of kidney function that sometimes occurs among people with type 1 diabetes. The study involves 17 visits to the Joslin Diabetes Center over a 3 year period and taking two allopurinol or inactive pills twice a day during this period. Study procedures will include blood tests, urine tests, and other medical tests to monitor kidney function. All medical procedures and medications are at no cost to the participant. Monetary compensation is available.

Recruitment:

Eligible patiets aged 18-60 who:
1) Have been diagnosed with type 1 diabetes before age 35
2) Have had diabetes for more than 8 years;
3) Have been told by their physician that they have kidney problems related to their diabetes, such as increased amounts of proteins in their urine.

Contact:

Study coordinators: Study Coordinators: Ben Flagg or Taneisha Vilma at (617) 309-4760 if you are interested in participating. Email at PERLStudy@joslin.harvard.edu.

UPDATED: 2/20/2014

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WANTED:

The RETAIN Study is a clinical research study evaluating a protein called alpha-1 antitrypsin (AAT) in recently diagnosed type 1 diabetes patients.

AAT is a naturally occurring anti-inflammatory protein that affects immune cells that are thought to be involved in the development of type 1 diabetes. In mice, an injection of AAT can halt the destruction of beta cells, so doctors want to know if it will do the same in people, in a safe manner.

Get more information.

UPDATED: 1/4/2012

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WANTED:

T1DAL (A Research Trial of Inducing Remission in New-onset Type 1 Diabetes with Alefacept)

This trial is testing whether repeated injections of an investigational study drug called alefacept (also called Amevive ) will help people with newly-diagnosed type 1 diabetes continue to make some of their own insulin.

T1DAL (A Research Trial of Inducing Remission in New-onset Type 1 Diabetes with Alefacept) is a phase II clinical research trial in which the investigational study drug (alefacept) is tested for safety and whether it is effective in slowing or halting the progression of type 1 diabetes.

This trial plans to enroll 66 participants at fifteen clinical research centers across the U.S.

Get more information.

UPDATED: 1/4/2012

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WANTED:

Driving Safely With Type 1 Diabetes

Research has shown that a few people with Type 1 diabetes are at an increased risk for having traffic accidents due to low blood sugars.

Researchers at the University of Virginia are conducting a study evaluating internet tools designed to:
Anonymously assess risk for all drivers with Type 1 diabetes of being in an accident and
Help reduce the chance of high-risk drivers being in a future collision.

The study is strictly confidential and the data collected will not be shared with any other person or agency. Participants may earn up to $270 in Internet gift cards.

Get More information. IRB-HSR# 15360

ADDED: 3/6/2012

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WANTED:

Monitoring Autoimmunity in Diabetes

Description: The purpose of the "Monitoring Autoimmunity in Diabetes" study is to look at changes in the body that may occur with the development of type 1 diabetes.  The samples taken as part of this study will be used to look at various genes, cells, and factors, which may be associated with type 1 diabetes and the immune system.  These will be used to study why some people are at higher risk for developing diabetes and what happens to the immune system with the development of the disease.   Participants may also qualify and be asked to participate in a separate clinical study that uses a novel magnetic resonance imaging (MRI) technique to noninvasively image insulitis (the destructive process in the pancreas that leads to loss of insulin production).

Recruiting: Seeking controls (no history of type 1 diabetes) and persons recently diagnosed with type 1 diabetes (within last 6 months).  Must be 18 years or older.

For more information, contact: Sarah Szubowicz at (617) 309-4493 or sarah.szubowicz@joslin.harvard.edu

ADDED: 3/6/2012

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WANTED:

The T1D Exchange Type 1 Diabetes Network (Pediatric, Adolescent and Young Adult Section)

Description: This Type 1 Diabetes (T1D) Exchange  is a nationwide registry collecting information about children and adults with type 1 diabetes.  The purpose of the registry is to gather information about people with type 1 diabetes to help better understand the natural course of type 1 diabetes and the effectiveness of current treatments. Participation in the registry involves completion of a questionnaire about medical and family history including diabetes diagnosis and treatment and laboratory test results.  Annual updates of information are also part of the registry.

Recruiting: At the Joslin, individuals being followed in the Pediatric, Adolescent and Young Adult Section may be eligible to participate in this registry.

Contact: Camille Ratliff at 617-309-4477 or camille.ratliff@joslin.harvard.edu (CHS#2011-01)

ADDED: 3/6/2012

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Type 2 Specific

WANTED:

The Yale Diabetes Center clinical study on type 2 diabetes

The Glycemia Reduction Approaches in Diabetes (GRADE) Study will compare the benefits and risks of four widely used diabetes drugs in combination with metformin. The study will compare drug' effects on glucose levels, quality of life, adverse effects, and diabetes complications.

You may qualify to participate in the study if:

• You were diagnosed with type 2 diabetes in the last five years. You may be on metformin, but not on any other diabetes medications.

Qualified participants will receive:

• Diabetes medications
• Laboratory Tests
• The most up-to-date treatments for their diabetes for up to seven years free of charge

For more information, visit grade.bsc.gwu.edu. You can also contact Yale's GRADE study coordinator, Patty Gatcomb, at 203-764-8463 or Michele Alguard, Yale recruitment coordinator, at 203-764-6649.

Added 7/3/13

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WANTED:

ELIXA Clinical Study on Type 2 Diabetes & Cardiovascular Disease

This is a research study of an investigational anti-diabetes medication to see if lowering blood sugar can prevent future cardiovascular events.

You may qualify to participate in the study if you:

  • are over 30 years of age
  • have had an Acute Coronary Syndrome event (heart attack/unstable angina) in the past 6 months

Qualified participants will receive:

  • study related medical exams
  • study-related investigational medication
  • all diabetes testing supplies
  • compensation for time and travel (where permitted)

For more information, call 1-800-788-0941 or visit http://www.hovclinicalresearch.com.

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WANTED:

Type 2 Diabetes & Cardiovascular Disease (Cleveland, OH)

If you have type 2 diabetes mellitus and have a history of cardiovascular disease, you may qualify for a clinical research study. The purpose of this research study is to test the safety and effectiveness of the study medication in controlling glucose levels in patients with a current history of cardiovascular disease.

Qualified candidates must be:

  • 18 years of age or older
  • Currently taking medication to control glucose levels but have not yet achieved the level of glucose control doctors want for you with your type 2 diabetes
  • Currently have a history of cardiovascular disease

Qualified participants will receive study medication and exams at no cost. Compensation will be provided for time and travel. Call Rapid Medical Research to see if you qualify at 888-460-2275 or visit http://www.rapidmedicalresearch.com/study-53-Type-2-Diabetes-&-Cardiovascular-Disease.

Find us on Facebook at http://www.facebook.com/RapidMedicalResearchInc.

ADDED: 11/26/2012

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WANTED:

Did you know that stress can affect your diabetes?

Taking steps to manage your stress can lead to you feeling better mentally and physically.  Researchers at the University of South Florida are offering adults with type 2 diabetes a free online program that will teach you ways that may help to manage your stress and improve your mood.  For more information visit www.diabetesstressrelief.com.  You can also contact the researcher directly at 1.800.576.3901 or diabetesstressrelief@gmail.com.

UPDATED: 1/4/2012

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WANTED:

Do you have type 2 diabetes? Are regular diet and exercise not working, or are you take Metformin and it's not enough?

If so, you may be eligible to be in a clinical research study evaluating the safety and effectiveness of an investigational medication for the treatment of type 2 diabetes.
Eligible volunteers will receive all study related:

  • Physical exams
  • Lab tests
  • Investigational medication(s) or placebo
  • Diet and exercise counseling
  • Glucometer and blood sugar testing supplies
  • Reimbursement for time and travel expenses

For more information, please call Diablo Clinical Research at 925-930-7267.

UPDATED: 1/4/2012

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WANTED:

Do you have type 2 Diabetes? We are enrolling adult volunteers now.

Help us explore pathways to diabetes management.

If you have type 2 diabetes, find out if you qualify for a clinical research study of an investigational oral diabetes medication.

You may be eligible if:

  • You have a confirmed diagnosis of type 2 diabetes, and
  • You are age 30 or older and have had a heart attack or stroke, or other heart or vascular problem OR
  • You are age 50 or older and you have been told by your doctor that you are at high risk for heart disease

If eligible to participate, you will be seen by a study doctor and receive study-related testing and study medication at no cost.

Once enrolled, you may be reimbursed for parking and travel expenses.

For more information, please contact Diablo Clinical Research at 925-930-7267.

UPDATED: 1/4/2012

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WANTED:

If you have type 2 diabetes, you may be interested in learning more about a clinical research study that may help with type 2 Diabetes.

You may qualify to participate in this study if you are between the ages 18 and 70 and have trouble controlling your blood sugar levels with your current regimen.

Study participants will receive at no cost:

  • Study-related medications
  • Diet and exercise counseling
  • Study-related medical care

Compensation for your time and travel may also be available.

For more information, please call Diablo Clinical Research at 925-930-7267.

UPDATED: 1/4/2012

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WANTED:

Do you have type 2 diabetes? Consider volunteering?

A clinical research study is evaluating how an investigational medication may give you better control of your type 2 diabetes. To qualify, you must be between 18 and 80 years of age and taking metformin alone, or in combination with another oral diabetes drug for three months or longer. Qualified participants will receive all study-related care and study medications at no cost, and may be compensated for time and travel.

For more information please call Diablo Clinical Research at 925-930-7267.

UPDATED: 1/4/2012

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WANTED:

The HARMONY Study

When your type 2 diabetes is out of control, finding Harmony is essential.

If you're having trouble controlling your diabetes, consider participating in HARMONY, a research study evaluating an investigational diabetes medication that's taken only once a week.

Even when you eat healthy, exercise, and take your prescribed medications, managing your blood sugar can still be a challenge. You're not alone. Many people living with type 2 have difficulty controlling their disease, even when they follow their current treatment plans.

Now, the HARMONY program is evaluating a new, investigational diabetes medication for its ability to better control Type 2 Diabetes. This investigational medication may not need to be taken as frequently as many current diabetes drugs, potentially making treatment more convenient for diabetes patients.

If you're having difficulty controlling your diabetes even with your current efforts, consider the HARMONY program.

UPDATED: 1/4/2012

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WANTED:

Do you want to change the future?

If you have type 2 diabetes, you can do something: Help others like you!

Diabetes is one of the most serious health problems of our time. People with type 2 diabetes have 2-4 times increased risk of heart disease.

To further understand the increased risk of heart disease and explore ways to reduce it, Diablo Clinical Research, Walnut Creek, CA, is seeking people with type 2 diabetes to take part in a new clinical study involving a novel treatment that has been demonstrated to improve glycemic control in people with type 2 diabetes.

To join the trial you must be:

  • Over the age of 50
  • Have type 2 diabetes and cardiovascular disease
  • Able to attend seven visits during the first year of the trial and two annual visit until the end of 2015

Patients included in the trial will receive study related care via regular health-checks and medical testing, access to trial medications and blood glucose testing equipment as well as compensation for your time and travel.

For more information, please contact Diablo Clinical Research at 925-930-7267.

UPDATED: 1/4/2012

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WANTED:

The Effects of Type 2 Diabetes on Brain Function Study


Description: In this study, we are looking at whether people with Type 2 diabetes show early signs of changes in their thinking processes. We are looking for people both with and without type 2 diabetes so we can compare their thinking processes.  The study involves 2 visits, one 2-4 hour visit to the Joslin Diabetes Center and one 1 hour visit to Beth Israel Medical Center in Boston.  Study procedures involve thinking tests, completing questionnaires, blood tests and a MRI Scan to examine performance on thinking tests. People without a prior diagnosis of diabetes will also be given a sugary drink at their visit to see how their body processes sugar.

Recruiting: Seeking participants between the ages of 45-65 with a diagnosis of Type 2 Diabetes who are not on metformin, or TZD's (pioglitazone, rosiglitazone).  We are also seeking participants between the ages of 45-65 who have not been diagnosed with Diabetes. Moderate proficiency in English is Required.   Monetary compensation is available and the study will validate parking on days of study visits.

Contact: If you are interested in learning more about this study, please call Veronica Flores at 617-309-4326 or by email at veronica.flores@joslin.harvard.edu (CHS#2010-04)

ADDED: 3/6/2012

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WANTED:

Study of Heart Disease in people with Type 2 Diabetes


Description: The study aims to identify the genes that cause some people with diabetes to be at a higher risk for developing heart disease. This is a one visit study. For all subjects the study involves completing questionnaires, brief physical exam, and blood samples. Subjects without history of heart disease will also have an exercise tolerance test unless they have had one within the past 12 months. Compensation and free parking are available, and all information will be held strictly confidential.

Recruiting: Joslin or BIDMC patients with type 2 diabetes and heart disease between 30 and 75 years old.  Joslin patients with type 2 diabetes and no heart disease between 55 and 75 years old.

Contact:  Elizabeth Goheen at 617-309-4165 or email elizabeth.goheen@joslin.harvard.edu (CHS#99-20)

ADDED: 3/6/2012

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WANTED:

SLIMM T2D Study: Surgery of Lifestyle with Intensive Medical Management in the treatment of Type 2 Diabetes


Description: We are comparing whether bariatric surgery (weight loss surgery) or a diabetes and intensive medical and weight management program is more effective for the treatment of type 2 diabetes in patients who are modestly overweight. Participants will be randomized (like the flip of a coin) to surgical or non-surgical treatment. Participants randomized to surgery will have their surgery performed at the Brigham and Women's Hospital, Boston.  Follow up visits for surgical groups can vary based on the type of surgery performed. Those participants randomized to the Intensive Medical Management program will have several visits at the Joslin Diabetes Center, Boston which include the following: Weekly evening meetings over 13 weeks for group education and support led by a physician, diabetes nurse educator, nutritionist, exercise physiologist and behavior counselor Monthly follow up visits after 13 weeks Both surgical and non-surgical groups are followed over three years.

Recruiting: We are seeking clinical Research Volunteers with type 2 diabetes and excess weight, between 21-65 years of age, who are willing to have bariatric (weight loss) surgery or participate in an intensive medical (non-surgical) diabetes and weight management program.

Contact: Kerri Clancy at 617-525-7388 or email SLIMMT2D@Partners.Org

ADDED: 3/6/2012

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WANTED:

Are you having gastric bypass surgery? Do you have type 2 diabetes?


We are looking for clinical research volunteers who are going to have a gastric bypass surgery for weight loss at Brigham and Women's Hospital and who have type 2 diabetes. We are conducting a study on how gastric bypass weight loss surgery helps to improve blood sugars in those with type 2 diabetes. The study involves 3 visits before your surgery, and 2 visits afterwards. The first visit will be at either Brigham and Women's Hospital or Joslin Diabetes Center, and all the visits after that will be at Joslin Diabetes Center. During these visits we will study how your body responds to sugar and the hormone insulin. We are looking for people 21 to 60 years of age. You will be compensated for your time. Please contact us if you would be willing to participate in this important research study.

Contact: Jennifer Panosian at 617-264-2731 or email jennifer.panosian@joslin.harvard.edu (CHS#2010-03)

ADDED: 3/6/2012

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WANTED:

Factors Affecting Type 2 Diabetes Treatment Adherence


Description:  This is research study investigating whether certain factors, such as the relationship with your physician, affect how you follow through with type 2 diabetes treatment recommendations (e.g., following a diet, exercising, monitoring blood sugar, etc.).

Eligible participants are asked to complete an anonymous online survey.  The survey should take no longer than 20 minutes to complete, and $2 will be donated to the American Diabetes Association for each survey submitted.

To access the survey, please clickhere

Recruiting: To participate, you must be: a) at least 18 years old; b)able to read and write in English; c) have received a diagnosisof type 2 disbetes at least two (2) years ago; d) able to carry out diabetes self-care activities on your own; and e) have met with the same physician who treats you for type 2 diabetes on at least three (3) separate occasions over the past two (2) years.

Contact: Please contact Jessie Fontanella, MSEd at (978) 807-3171 or fontanella@fordham.edu

ADDED: 3/6/2012

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Gastroparesis Trials

WANTED:

Study Evaluating the Effect of TC-6499 on Gastric Emptying Time in Diabetic Subjects With Gastroparesis

This is a 4-way crossover study to assess the effect of TC-6499 on gastric emptying time in diabetic subjects with gastroparesis. The length of study participation for a subject is up to 50 days. During screening, eligible subjects will complete an oral 13-C-spirulina breath test also known as the Gastric Emptying Breath Test (GEBT). During the treatment period, subjects will complete 4 overnight drug assessment visits (treatment arms) where they will receive a randomized single dose of study drug and the GEBT. Each overnight visit will be separated by approximately 7 days. At least 18 subjects will be randomized and complete all 4 dosing arms.

Eligibility:
Ages Eligible for Study:  18 to 70
Genders Eligible for Study:  Both
Accepts Healthy Volunteers:  No

To be included in the trial, you must have:
• A diagnosis of gastroparesis or symptoms consistent with gastroparesis for at least 6 months (and Gastroparesis Cardinal Symptoms Index total score >22)
• Gastroparesis confirmed using the GEBT
• Type 1 or Type 2 diabetes with a Hemoglobin A1c = 10%
• Fasting blood glucose (finger stick) = 275 mg/dL prior to each GEBT
• Body Mass Index (BMI) = 40
• Willingness to remain in clinical research facility for the protocol-required days of treatment and study procedures
• Willingness to use a double barrier method of birth control (except post-menopausal females)
• Able to understand study procedures and provide written informed consent

For more information, visit ClinicalTrails.gov.

ADDED: 9/24/2014

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Neuropathy Trials

WANTED:

Is diabetes causing you pain in both legs or both feet? For at least the past 6 months?

If so, please contact our medical research study of an investigational medication for the pain in both legs or both feet caused by diabetes.

Qualified participants:

  • Are 18 to 70 years old
  • Have pain in both legs or both feet caused by diabetes
  • Have experienced this pain for at least the past 6 months

Qualified participants will receive all study-related care, evaluations, and medications at no charge.

Participation is at no charge and compensation is available for time and travel.

To learn more, please call Diablo Clinical Research at 925-930-7267.

UPDATED: 1/4/2012

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WANTED:

Are you a diabetic and have pain in your feet?

Diablo Clinical Research is currently conducting a clinical trial to test an investigational medication for people that have diabetes and suffer from Neuropathy (pain in feet). Qualified participants must be 18 to 75 years of age, in good general health and able to attend 9 scheduled visits.

Qualified Participants May Receive:

  • Investigational medication administered by intravenous infusion
  • Compensation for time and travel

For more information please call Diablo Clinical Research at 925-930-7267.

UPDATED: 1/4/2012

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Pediatric Diabetes Specific

WANTED:

The T1D Exchange Type 1 Diabetes Network


Description: The Type 1 Diabetes (T1D) Exchange ia a nationwide registry collecting information about children and adults with type 1 diabetes.  The purpose of the registry is to gather information about people with type 1 diabetes to help better understand the natural course of type 1 diabetes and the effectiveness of current treatments.  Participation in the registry involves completion of a questionnaire about medical and family history including diabetes diagnosis and treatment and laboratory test results  Annual updates of information are also part of the registry.

Recruiting: At the Joslin, individuals being followed in the Pediatric, Adolescent and Young Adult Section may be eligible to participate in this registry.

Contact: Camille Ratliff at (617) 309-4477 or Camille.Ratliff@Joslin.Harvard.edu (CHS#2011-01)

ADDED: 3/6/2012

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WANTED:

The Tolerance Study


Description: This study is trying to help us better understand what causes type 1 diabetes to help find new ways to prevent or reverse the disease. The study is being done with researchers at Harvard Medical School and is funded by the Juvenile Diabetes Research Foundation. The study visit includes the completion of questionnaires and a blood draw.

Recruiting: Individuals, ages 18 years and older, both with and without type 1 diabetes.

Contact: Roxanne Phillips at 617-309-2481 or roxanne.phillips@joslin.harvard.edu (CHS#02-15)

ADDED: 3/6/2012

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WANTED:

CGM improve study


Description: The purpose of this study is to find out how to make it easier for children and teens with type 1 diabetes to use continuous glucose monitors (CGM) over a long period of time. The study involves 12 visits over a 24-month period with additional phone contacts between visits. The extra three visits occur during the first six months of the study: the rest of the visits will occur at routine clinic visits. Families randomized to the intervention group will receive a family based behavioral intervention providing support and education regarding use of the CGM. Families in the usual care group will receive this information at the end of the study. Youth in both groups will wear a CGM device throughout the study. Families will be asked to complete surveys at various intervals over the course of the study and lab work will be collected for the youth in the study.

Recruiting: Children and teens, ages 8-17 years, who have had type 1 diabetes for at least 1 year and who are receiving care at Joslin and their parents or legal guardians.

Contact: Kaitlin Gaffney at 617-309-4475 or kaitlin.gaffney@joslin.harvard.edu (CHS#2010-28)

ADDED: 3/6/2012

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WANTED:

Type 1 Diabetes Risk Assessment- The Natural History Study - TrialNet


Description: This study aims to identify youth and adults at risk for type 1 diabetes by testing for diabetes-related antibodies in relatives of people with type 1 diabetes. It involves a single blood test. People who test positive will be eligible for further testing and may be eligible to participate in prevention trials.

Recruiting: Parents, children, & siblings, ages 1-45, and cousins, grandchildren, nieces, & nephews, ages 1-20, of people with type 1 diabetes.

Contact: Hui Zhang at 617-309-2524 or hui.zhang@joslin.harvard.edu (CHS#03-33)

ADDED: 3/6/2012

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Not Diabetes Specific

WANTED:

SUGAR MGH Study: Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans


Description: The SUGAR MGH Research Study will evaluate whether the different genes people inherit change the response to medications that are commonly used to treat type 2 diabetes, metformin and glipizide.  As part of the study participants will be asked to take these medications and will also be given a sugar drink. 

The study involves two visits to the Joslin Diabetes Clinic one week apart, the first visit takes about 5 hours and the second about 3 hours.  Blood will be drawn at both visits.  Participants will receive monetary compensation, a parking voucher and a free meal for each completed visit. 

Recruiting: We are seeking research volunteers over the age of 18 years who have diabetes but are not currently on diabetes medication, and/or who may be at risk for diabetes (for example, risk factors include high or "borderline-high" blood sugars, being overweight, having a history of gestational diabetes (diabetes during pregnancy), being an ethnic minority, or having a first degree relative with type 2 diabetes). 

Contact: Corinne Barbato at corinne.barbato@joslin.harvard.edu or 617-309-4478

ADDED: 3/6/2012

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WANTED:

Gastric Bypass Study


Are you feeling well after your gastric bypass surgery 2-5 years ago and between the ages of 30 and 60? Researchers at the Joslin Diabetes Center are seeking volunteers to participate in a research study to investigate people who have successfully lost weight after gastric bypass surgery.

Study involves two, 6-hour visits to the Boston Joslin Diabetes Center. Free Parking. Monetary compensation.

Contact: Jennifer Panosian at 617-264-2731 or email at jennifer.panosian@joslin.harvard.edu (CHS # 91-04)

ADDED: 3/6/2012

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Last Modified Date: September 24, 2014

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by Lindsey Guerin
Last Saturday, I’d been struggling with an entire week above 200 that just didn’t seem to want to budge. So I decided that I couldn’t risk the Omnipod anymore and I had to pull it from my management routine, at least until things settled down. I started twice-daily Lantus injections on Saturday night and have been working out the kinks of being back on MDIs since then. The first three days of switching to MDIs were rough. Watching the Lantus take effect slowly was like waiting for...