Other SGLT-2s in Development

The recent approval of Invokana is exciting, opening the door to a new class of medications that can help people to manage type 2 diabetes, but it was not exactly the only drug on that long road to approval. Take a look at other potential medications that are in various stages of trials and approvals that may join this newest class of oral medications.

Astellas Pharma – Ipragliflozin

  • This drug has been filed for marketing approval in Japan and is in the process of completing phase III trials.
  • Trials have shown its potential to significantly lower glycated hemoglobin levels (HbA1c) over time as compared to placebo.

Bi/Lilly – Empagliflozin

  • This drug is in Phase III of clinical trial process involving over 14,500 patients.  There will be a total of 12 clinical trials performed throughout several countries.
  • It is said that the companies will present results of the studies at some point in 2013 or 2014.

Chugai (Roche) – Tofogliflozin Hydrate

  • According to Chugai Pharma, as of November 2010, this drug is in Phase III of clinical trials.

Lexicon – LX4211

  • This drug inhibits both SGLT1 and SGLT2, making it the first of its kind to be introduced in clinical development for diabetes.
  • LX4211 will begin Phase III clinical studies in the middle of 2013.

Taisho Pharma – luseogliflozin

  • This drug is currently in Phase III of clinical trials.

Bristol-Myers Squibb Farxiga

  • This is a once- daily oral treatment specifically geared toward type 2 diabetes, to be used in conjunction with exercise and a proper diet. This treatment is currently in clinical trials.

Reviewed by James A. Bennett 04/14.

Last Modified Date: April 04, 2014

All content on dLife.com is created and reviewed in compliance with our editorial policy.
  1. • Astellas. AVEO and Astellas announce postive findings from TIVO-1 superiority study of tivozanib in first line advanced RCC., http://www.astellas.com/en/corporate/news/pdf/121003_Eg_1.pdf. (PDF) (Accessed 4/11/13.)
  2. • Lexicon Pharmaceuticals. LX4211, http://www.lexgen.com/pipeline/lx4211.html. (Accessed 4/11/13.)
  3. • Chugai Pharma USA. Annual report, 2011. http://www.chugai-pharm.co.jp/hc/ss/downloads/eAR2011_12_09.pdf?blobheader=application%2Fpdf&blobheadername1=content-disposition&blobheadervalue1=inline%3Bfilename%3DeAR2011_12_09.pdf&blobwhere=1259656736395&ssbinary=true. (PDF) (Accessed 4/11/13.)
  4. • Theheart.org. FDA approves new diabetes drug, canagliflozin, despite CV concerns, http://www.theheart.org/article/1523789.do. (Accessed 4/11/13.)
  5. • Drug Discovery & Development Magazine. Lilly, BI submit empagliflozin to FDA, http://www.dddmag.com/news/2013/03/lilly-bi-submit-empagliflozin-fda. (Accessed 4/11/13.)

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