Riomet (Metformin HCl Oral Solution)
What is Riomet?
Riomet is to be used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes. Riotmet is available as a 500-mg/5-mL oral solution. Each 5-mL of Riomet is equivalent to the 500 mg tablet form of metformin. The solution contains no alcohol, dyes or sugars.
Riomet contains 500 mg of metformin hydrochloride per 5 mL and the following inactive ingredients: saccharin calcium, potassium bicarbonate, xylitol, hydrochloric acid, purified water and cherry flavor.
Who can take Riomet?
Type 2 diabetes patients age 10 years and older can use this solution. Riomet should not be given to patients 80 years of age or unless measurement of creatinine clearance demonstrates that renal function is not reduced.
Who can not take Riomet?
Riomet is not recommended for pregnant women.
It is not for patients with:
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.
- Renal disease or renal dysfunction
o Which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicemia.
- Congestive heart failure requiring pharmacologic treatment
- Known hypersensitivity to metformin hydrochloride
Riomet should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because use of such products may result disrupt renal function.
What dosage can I take and how should I take it?
Dosage should be prescribed by your doctor. It must be individualized on the basis of effectiveness and tolerance, while not exceeding the maximum recommended daily dose. The maximum recommended daily dose of Riomet is 2550-mg (25.5mL) in adults and 2000-mg (20mL) in pediatric patients (10 to 16 years of age).
Riomet should be given in divided doses with meals. It should be started at a low dose, with gradual dose escalation, both to reduce gastrointestinal side effects and to allow the identification of the minimum dose required for adequate glycemic control of the patient.
Riomet should noy be taken with alcohol.
What are the side effects?
Possible side effects include diarrhea, nausea/vomiting, flatulence, asthenia, indigestion, abdominal discomfort, and headache.
Hypoglycemia does not occur in patients receiving Riomet alone under usual circumstances of use.
Riomet contains a black box warning for lactic acidosis. Lactic acidosis, a rare and potentially life-threatening condition, is caused by metformin accumulation and occurs primarily in patients with significant renal insufficiency. Lactic acidosis can result in muscle pain and weakness, nausea and vomiting, and abdominal pain. When it occurs, it is fatal in approximately 50% of cases. To find out the symptoms and predisposing conditions, consult your doctor.
Reviewed by James A. Bennett 5/13.
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