Brand Name (Generic Name)

Prandin (repaglinide)

What is repaglinide?

Repaglinide (brand name Prandin) is one of the members of the group of diabetes medicines that we have nicknamed "glinides". Repaglinide is the first of the glinides to be marketed in the US. The glinides are taken just before meals and cause the pancreas to release insulin. They primarily help control after meal blood sugars. This medicine only seems to work for about four to six hours after a dose but that is an advantage because it may cause less low blood sugar problems.

Who can take repaglinide?

Selected adults with type 2 diabetes can take repaglinide.

Who should not take it?
• Those with type 1 diabetes or diabetic ketoacidosis
• People with impaired kidney or liver function
• Women who are pregnant or breastfeeding


Since the glinides have a shorter duration of action they seem to cause less hypoglycemia than the long acting drugs that stimulate insulin output. They are a better choice than the long acting sulfonylureas (SFUs) for this reason, especially for people who have erratic eating habits and often skip or delay meals. Repaglinide should not be taken if the meal is going to be skipped. It can also be given in combination with some of the other diabetes medicines.


Repaglinide must be timed correctly and taken about 15-30 minutes before each major meal up to four times daily. Remember the dose should not be taken if the meal is going to be skipped.

What dosage can I take and how should I take it?

The initial dosage is .5 mg 15-30 minutes before each meal, and can be increased on a weekly basis up to 4 mg before meals. It may be taken up to four times a day if you eat four times in a day. The maximum total daily dose is 16 mg in one 24 hour period. If you skip a meal, you should not take the dose of repaglinide.

What are most common side effects?
• Low blood sugar, especially if you take the medicine and fail to eat afterward
• Upper respiratory symptoms or flu like symptoms
• Back pain
• Diarrhea
• Dizziness

Reviewed by James A Bennett 5/14

Last Modified Date: June 09, 2014

All content on is created and reviewed in compliance with our editorial policy.

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