Brand Name (Generic Name)
Januvia (sitagliptin phosphate)
What is Januvia?
Januvia is an orally active inhibitor of dipeptidyl enzymes, which helps to control high blood sugar. It is responsible for increasing beta-cell insulin production and decreasing the production of glucagons in response to blood glucose levels (i.e. when blood glucose levels are high, insulin production is boosted and glucose production by the liver drops off). It amplifies the response and reaction of a "normal" pancreas to high blood sugar levels. This mechanism does not work when your blood sugar is low so hypoglycemia is unlikely. Januvia has shown weight loss benefits in clinical trials and also appears to preserve beta cell function.
Who can take it? Who can't?
Adults with type 2 diabetes can take Januvia. It should not be used to treat people with type 1, and keep in mind that when used in combination with insulin or a sulfonylurea, your risk of low blood sugar is increased. If you have a history of kidney or pancreas disease, you should avoid Januvia.
What dosage can I take and how should I take it?
The initial dosage is 100 mg, taken by mouth once daily, with or without food.
How often should I take sitagliptin phosphate?
Once a day, as your doctor may suggest. Your doctor may also prescribe this medication in conjunction with metformin, Actos, or Avandia.
When should I take sitagliptin phosphate?
Sitagliptin phosphate can be taken with or without food. You doctor should tell you what will work best for you.
What are possible side effects?
- Upper respiratory infection
- Stuffy or runny nose and sore throat
- Stomach discomfort
Are other diabetes medications used with it?
Other diabetes medications may be used with Januvia. You are encouraged to consult with your doctor to learn about the interactions between it and medications you are taking.
What should I tell my doctor before taking Januvia?
Tell your doctor if you are taking other medications, as well as general allergies or allergies you have to the ingredients of Januvia. You should also let your doctor know if you have a history of pancreas or kidney disease.
Reviewed by James A. Bennett 5/13
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