Brand Name (Generic Name)

Januvia (sitagliptin phosphate)

What is Januvia?

Januvia is an oral prescription medicine used along with diet and exercise to control high blood sugar in adults with type 2 diabetes. It is a member of the DPP4 Inhibitor family of medicines that we have nicknamed "gliptins". Januvia works by enhancing the body's natural ability to control high blood sugar. As your blood sugar begins to go up after a meal, Januvia goes to work by asking the pancreas to put out more insulin and it also keeps the liver from putting out unneeded glucose. These two actions together tend to lower your blood sugar particularly after meals. As the blood sugar goes down to normal levels the Januvia backs away so that is why it usually does not cause your blood sugar to drop too low.

Who can take Januvia?

Selected adults with type 2 diabetes can take Januvia and it can be used in combination with some of the other diabetes medicines.

Who should not take Januvia?

It should not be used to treat people with type 1 diabetes or to treat diabetic ketoacidosis (dangerously high levels of certain acids, known as ketones, in the blood or urine). Talk to your healthcare provider if you are pregnant, plan to become pregnant, or are breast feeding before starting Januvia. It must be used with caution if you have a history of reduced kidney function or pancreas disease, you should use caution in taking Januvia.


When used alone Januvia is unlikely to cause your blood sugar to be lowered to a dangerous level (hypoglycemia) because it does not cause insulin to be secreted when blood sugar is normal or low. It can be used alone or together with one of several common oral diabetes medicines, such as metformin, a thiazolidinedione (TZD), or a sulfonylurea. It seems to work even better in combination that it does alone.

What dosage can I take and how should I take it?

Januvia is taken one time each day, most often at the 100 mg dose and can be taken with or without food.

What are the common side effects?

• Upper respiratory infection
• Stuffy or runny nose and sore throat
• Headache
• Stomach discomfort and diarrhea
• These are not all the possible side effects so tell your healthcare provider if you have side effects that are bothersome and do not go away.

Download the Januvia medication guide.

Reviewed by James A. Bennett 5/14

Last Modified Date: July 07, 2014

All content on dLife.com is created and reviewed in compliance with our editorial policy.

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by Brenda Bell
Years before I was diagnosed with type 2 diabetes, The Other Half came out of a doctor's appointment with a diagnosis of "borderline diabetes" and an ADA exchange diet sheet. His health insurance agency followed up on the diagnosis with a glucometer and test strips. After a year or so of trying to follow the diet plan and test his glucose levels, things appeared to be back in "normal" range, and stood there until a couple of years after my own diagnosis. Shortly...
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