Brand Name (Generic Name)

Starlix (nateglinide)

What is nateglinide?

Nateglinide (nah-TAG-lin-ide) is one of the members of a group of diabetes medicines we call "glinides". Nateglinide lowers blood glucose by stimulating the release of insulin from the pancreas. There are several "families" of medicines that stimulate the pancreas to produce insulin but the glinides have their own way of doing it which is a little different than some of the others. The glinides are taken just before meals and cause insulin release that primarily helps control after meal blood sugars. They only seem to work for about four hours after a dose but that is an advantage because they seem to cause less low blood sugar problems.

Who can take nateglinide?

Selected adults with type 2 diabetes can take nateglinide.

Who should not take it?
• Those with type 1 diabetes, diabetic ketoacidosis
• People with impaired kidney or liver function
• Women who are pregnant or breastfeeding


Since these medicines have a shorter duration of action they seem cause less hypoglycemia than the long acting drugs that stimulate insulin output. They are a better choice than the long acting sulfonylureas (SFUs) for this reason, especially for people who have erratic eating habits and often skip or delay meals. They can also be given in combination with some of the other diabetes medicines.


They must be taken about 30 minutes before each major meal up to three times daily. The dose should not be taken if the meal is skipped.

What dosage can I take and how should I take it?

Nateglinide is taken at a dose of 60-120 mg three times daily up to 30 minutes before meals. It is not to be taken more than three times daily.

What are most common side effects?
• Low blood sugar, especially if you take the medicine and fail to eat afterward
• Upper respiratory symptoms or flu like symptoms
• Body aches and pains
• Dizziness
• Increased uric acid

Reviewed by James A. Bennett 5/14.

Last Modified Date: June 09, 2014

All content on dLife.com is created and reviewed in compliance with our editorial policy.

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