dLife - Inhaled Insulin
Inhaled Insulin: The Facts
In early 2006, Exubera became the first inhaled insulin product cleared for U.S. sale – marking what was arguably the biggest advance in insulin therapy since the drug was first administered to a patient in 1922. A powdered insulin administered through the mouth via an inhaler, Exubera was approved for use in type 1 and type 2 adult patients (i.e., over 18) who take insulin for use at mealtime. But Exubera faced an uphill battle winning widespread physician and consumer adoption, and in October of 2007, manufacturer Pfizer announced that it would pull the product from its portfolio.
Other Products in the Inhaled Insulin Pipeline
There are several other inhaled insulin products and inhaler systems in various stages of product development and/or clinical trials:
Eli Lilly and Co. in partnership with Alkermes, Inc. is developing the the AIR® Inhaled Insulin System (AIR® Insulin System). It is currently in stage 3 of clinicial development and is being studied as treatment for both type 1 and type 2 diabetes.
Kos Pharmaceuticals Inc. – Metered Dose Inhaler (MDI) is continuing its inhaled insulin study.
MannKind Corp. – Technosphere Delivery System will be submitting final approval in 2008 for the new inhaled Supra-Rapid Acting insulin. It will be for mealtime insulin delivery for people with type 1 and type 2 diabetes. It is expected to be a first in a new class of medications.
Novo Nordisk Refocuses Its Activities Within Inhaled Insulin and Discontinues the Development of AERx® (Updated 01/14/08)
Expert Q & A
Keith Campbell, RPh talks about the pros and cons of inhaled insulin Last Updated: 1/31/06
See how the Exubera inhaled insulin system works. (Pfizer, Inc.)
Dr. Robert Meyer of the U.S. FDA speaks about Exubera's January 2006 approval. (Originally broadcast 1/31/06.) Listen
dLife's Janis Roszler talks to diabetes expert Dr. Steve Edelman about inhaled insulin. (Originally broadcast 1/31/06.) Listen
Coney Island Hot Dog Sauce Soybean and Vegetable Spread Cheesy Vegetables au Gratin Anise Seed Meatloaf Warm Blueberry Crumbly Spinach and Artichoke Cheese Custard Braised Whole Artichokes Apple Dressing Chocolate Almond Cheesecake Salmon Pate
Last Saturday, I’d been struggling with an entire week above 200 that just didn’t seem to want to budge. So I decided that I couldn’t risk the Omnipod anymore and I had to pull it from my management routine, at least until things settled down. I started twice-daily Lantus injections on Saturday night and have been working out the kinks of being back on MDIs since then. The first three days of switching to MDIs were rough. Watching the Lantus take effect slowly was like waiting for...