dLife - Inhaled Insulin

Inhaled Insulin: The Facts

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In early 2006, Exubera became the first inhaled insulin product cleared for U.S. sale – marking what was arguably the biggest advance in insulin therapy since the drug was first administered to a patient in 1922. A powdered insulin administered through the mouth via an inhaler, Exubera was approved for use in type 1 and type 2 adult patients (i.e., over 18) who take insulin for use at mealtime. But Exubera faced an uphill battle winning widespread physician and consumer adoption, and in October of 2007, manufacturer Pfizer announced that it would pull the product from its portfolio.

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Other Products in the Inhaled Insulin Pipeline
There are several other inhaled insulin products and inhaler systems in various stages of product development and/or clinical trials:

Eli Lilly and Co. in partnership with Alkermes, Inc. is developing the the AIR® Inhaled Insulin System (AIR® Insulin System). It is currently in stage 3 of clinicial development and is being studied as treatment for both type 1 and type 2 diabetes.

Kos Pharmaceuticals Inc. – Metered Dose Inhaler (MDI) is continuing its inhaled insulin study.

MannKind Corp. – Technosphere Delivery System will be submitting final approval in 2008 for the new inhaled Supra-Rapid Acting insulin. It will be for mealtime insulin delivery for people with type 1 and type 2 diabetes. It is expected to be a first in a new class of medications.

Novo Nordisk Refocuses Its Activities Within Inhaled Insulin and Discontinues the Development of AERx® (Updated 01/14/08)


Expert Q & A
Keith Campbell, RPh talks about the pros and cons of inhaled insulin Last Updated: 1/31/06

Video
See how the Exubera inhaled insulin system works. (Pfizer, Inc.)

Podcasts
Dr. Robert Meyer of the U.S. FDA speaks about Exubera's January 2006 approval. (Originally broadcast 1/31/06.) Listenlisten_icon

dLife's Janis Roszler talks to diabetes expert Dr. Steve Edelman about inhaled insulin. (Originally broadcast 1/31/06.) Listen listen_icon
 

Last Modified Date: November 27, 2012

All content on dLife.com is created and reviewed in compliance with our editorial policy.

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by Nicole Purcell
I had a bad one last night. A scary low bloodsugar that reminded me just how tenuous diabetes makes my existence. I hate those. I hate the feeling that I'm anything less than a strong, capable woman. Diabetes, like a sledge hammer to the knees, has a way of hobbling the confidence I have in my health, strength and well-being. It is both frustrating and disheartening. It's 2:00 am and a good friend called from their third shift job because they needed someone. Just...