dLife - Inhaled Insulin
Inhaled Insulin: The Facts
In early 2006, Exubera became the first inhaled insulin product cleared for U.S. sale – marking what was arguably the biggest advance in insulin therapy since the drug was first administered to a patient in 1922. A powdered insulin administered through the mouth via an inhaler, Exubera was approved for use in type 1 and type 2 adult patients (i.e., over 18) who take insulin for use at mealtime. But Exubera faced an uphill battle winning widespread physician and consumer adoption, and in October of 2007, manufacturer Pfizer announced that it would pull the product from its portfolio.
Other Products in the Inhaled Insulin Pipeline
There are several other inhaled insulin products and inhaler systems in various stages of product development and/or clinical trials:
Eli Lilly and Co. in partnership with Alkermes, Inc. is developing the the AIR® Inhaled Insulin System (AIR® Insulin System). It is currently in stage 3 of clinicial development and is being studied as treatment for both type 1 and type 2 diabetes.
Kos Pharmaceuticals Inc. – Metered Dose Inhaler (MDI) is continuing its inhaled insulin study.
MannKind Corp. – Technosphere Delivery System will be submitting final approval in 2008 for the new inhaled Supra-Rapid Acting insulin. It will be for mealtime insulin delivery for people with type 1 and type 2 diabetes. It is expected to be a first in a new class of medications.
Novo Nordisk Refocuses Its Activities Within Inhaled Insulin and Discontinues the Development of AERx® (Updated 01/14/08)
Expert Q & A
Keith Campbell, RPh talks about the pros and cons of inhaled insulin Last Updated: 1/31/06
See how the Exubera inhaled insulin system works. (Pfizer, Inc.)
Dr. Robert Meyer of the U.S. FDA speaks about Exubera's January 2006 approval. (Originally broadcast 1/31/06.) Listen
dLife's Janis Roszler talks to diabetes expert Dr. Steve Edelman about inhaled insulin. (Originally broadcast 1/31/06.) Listen
E-Z Strawberry Cheesecake BBQ Bacon-Wrapped Shrimp with Basil Stuffing Savory Roasted Mixed Nuts Fruit Salad Medley Breakfast Burritos Pork in Bourbon Maple Marinade Very Berry Soup Gingered Rhubarb-Berry Sauce Grilled Glazed Peaches Cucumber Soup
Yesterday was pretty horrible. Today is better. So far … Yesterday morning’s Dexcom graph was Mount Kilimanjaro. Today we have a dorsal fin, jutting out of the water at about 200 before descending into a connect-the-dots shark. He appears to be 63 at lunchtime versus three-hundred-something yesterday. Not perfect, but it never is. Charlie’s teacher and the nurse mentioned that he didn’t look like himself yesterday. He had taken too many body blows from diabetes...