dLife - Inhaled Insulin
Inhaled Insulin: The Facts
In early 2006, Exubera became the first inhaled insulin product cleared for U.S. sale – marking what was arguably the biggest advance in insulin therapy since the drug was first administered to a patient in 1922. A powdered insulin administered through the mouth via an inhaler, Exubera was approved for use in type 1 and type 2 adult patients (i.e., over 18) who take insulin for use at mealtime. But Exubera faced an uphill battle winning widespread physician and consumer adoption, and in October of 2007, manufacturer Pfizer announced that it would pull the product from its portfolio.
Other Products in the Inhaled Insulin Pipeline
There are several other inhaled insulin products and inhaler systems in various stages of product development and/or clinical trials:
Eli Lilly and Co. in partnership with Alkermes, Inc. is developing the the AIR® Inhaled Insulin System (AIR® Insulin System). It is currently in stage 3 of clinicial development and is being studied as treatment for both type 1 and type 2 diabetes.
Kos Pharmaceuticals Inc. – Metered Dose Inhaler (MDI) is continuing its inhaled insulin study.
MannKind Corp. – Technosphere Delivery System will be submitting final approval in 2008 for the new inhaled Supra-Rapid Acting insulin. It will be for mealtime insulin delivery for people with type 1 and type 2 diabetes. It is expected to be a first in a new class of medications.
Novo Nordisk Refocuses Its Activities Within Inhaled Insulin and Discontinues the Development of AERx® (Updated 01/14/08)
Expert Q & A
Keith Campbell, RPh talks about the pros and cons of inhaled insulin Last Updated: 1/31/06
See how the Exubera inhaled insulin system works. (Pfizer, Inc.)
Dr. Robert Meyer of the U.S. FDA speaks about Exubera's January 2006 approval. (Originally broadcast 1/31/06.) Listen
dLife's Janis Roszler talks to diabetes expert Dr. Steve Edelman about inhaled insulin. (Originally broadcast 1/31/06.) Listen
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With Charlie home now for the summer and under Susanne’s watchful eye, you would think there’s no need for me to plug in NightScout at all. Why would I need to watch blood sugars while at work each day? What good would that do? The whole point of the thing was to be a second (or third) set of eyes when Charlie was at school or at a friend’s house or in Japan. BECAUSE I’M A CRAZY PERSON!!!!!!!!! That’s why. Watching Charlie’s numbers like...