Neurogenic Bladder: Bladder Urethra
What are the treatments for lack of coordination between the bladder and urethra?
The job of the sphincter muscles is to hold urine in the bladder by squeezing the urethra shut. If the urethral sphincter fails to stay closed, urine may leak out of the bladder. When nerve signals are coordinated properly, the sphincter muscle relaxes to allow urine to pass through the urethra as the bladder contracts to push out urine. If the signals are not coordinated, the bladder and the sphincter may contract at the same time, so urine cannot pass easily.
Drug therapy for an uncoordinated bladder and urethra. Scientists have not yet found a drug that works selectively on the urethral sphincter muscle, but drugs used to reduce muscle spasms or tremors are sometimes used to help the sphincter relax. Baclofen (Lioresal) is prescribed for muscle spasms or cramping in patients with multiple sclerosis and spinal injuries. Diazepam (Valium) can be taken as a muscle relaxant or to reduce anxiety. Drugs called alpha-adrenergic blockers can also be used to relax the sphincter. Examples of these drugs are alfuzosin (UroXatral), tamsulosin (Flomax), terazosin (Hytrin), and doxazosin (Cardura). The main side effects are low blood pressure, dizziness, fainting, or nasal congestion. All of these drugs have been used to relax the urethral sphincter in patients where the sphincter does not relax well.
Botox injection. Botulinum toxin type A (Botox) is best known as a cosmetic treatment for facial wrinkles. Doctors have also found that botulinum toxin is useful in blocking spasms like eye ticks or relaxing muscles in patients with multiple sclerosis. Urologists have found that injecting botulinum toxin into the tissue surrounding the sphincter can help the sphincter to relax. Although the FDA has approved botulinum toxin only for facial cosmetic purposes, researchers are studying the safety and effectiveness of botulinum toxin injection into the sphincter for possible FDA approval in the future.
Adapted and excerpted from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Reviewed by Francine Kaufman, MD. 01/09
Melon Salad With Citrus Mint Dressing Thai Hot-and-Sour Soup Wild Rice with Almonds Homestyle Turkey Gravy Whole Wheat Soda Bread Pepper and Garlic Crusted Tenderloin Peanut Butter and Banana Chocolate Muffins Chocolate Applesauce Cupcakes Cowboy Potatoes Graham Cookies
The past few days, we've been warned of near-record cold and wind conditions. While we've not been buried in the snow (that's been Boston's issue this winter), this weekend has seen temperatures as low as the single digits, with wind chills below zero (Fahrenheit). For someone with cold-weather neuropathy (among other issues), this can be an issue. (At the moment, it's the pins and needles in my right hand, the sprain-like feeling in my left wrist, and the right-elbow...