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The Question
03/20/10 11:09 AM

"Can you explain how drugs on your list of DRUGS THAT CAN AFFECT BLOOD GLUCOSE LEVELS actually affects levels? "
Asked By: sas7394  
Category: Other

Background Info Hide
I take Lisinopril-Hctz (Zestortic); should I be concerned?

Expert Answers (1)

04/07/10 08:25 AM

Hello sas7394
Medication side effects and interactions are always a concern that you and your provider should discuss in detail. Frequent laboratory studies are essential in tracking how your body is reponding to treatment both in a positive or a negative way. Good communication between patient and doctor is key to recognizing problems.

The medication you listed in your profile is a combination drug. Let's look at them individually

Lisinopril is a ACE inhibitor. ACE stands for Angiotensin Converting Enzyme. This drug inhibits this enzyme. It works through the kidney and it lowers blood pressure. Side effects relating to the metabolic system, and therefore possibly effecting diabetics include a rise in serum insulin levels. Cases of hypoglycemia have been reported when used in combination with oral diabetic medications or insulin. This is why you should always monitor your glucose levels when any change in medications is ordered. Lisinopril is a recommended first line medication for diabetics that have high blood pressure. Lisinopril has an added "good" side effect of increasing the GFR Glomerular Filtration Rate meaning it improves kidney function.

HCTZ is Hydrochlorothiazide a thiazide diuretic (water pill). In reviewing the literature, I do not see where it effects the glucose levels in patients but because diabetes causes dehydration and this drug works by decreasing water load in the body, it can be a problem that causes concern. HCTZ is ordered to reduce water and lessen the edema in extremities. This decreases the workload on the heart.

Both Lisinopril and HCTZ are first line blood pressure medications orderd for many patients. Good monitoring of your labs by your doctor and self-monitoring of your glucose levels along with reporting any side effcts to your doctor promptly should allow these medicationsto do their job well with very little risk.. Remember, there is always risk versus benefit in all treatments for all conditions.

Answered By: Rita Juray
Accreditations: RN, MLT-ASCP, CCM, CDE
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