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The Question
11/22/09 10:19 AM

"Fasting Glucose Levels too LOW in the morning"
Asked By: nhtom1160  
Category: Type 2

Background Info Hide
I have read a lot of different articles about glucose levels being too high in the morning. I have had the opposite. The other day, my a.m glucose was 64. This morning it was 62. Other readings at lunch or dinner have been in the range of 86-117. What could cause low a.m numbers?

Expert Answers (1)

12/12/09 08:45 PM

Hello NhTom1160:
Thanks for asking dLife and sorry for the lag time in response. Ty2 is known for variable pancreatic functions and insulin resistance.

You indicate you have done a great deal of homework; however, you did not mention the oral hypoglycemic medication(s) you take, its action or frequency.

To date: several medications are available and have organ/site specific pre-programmed performances:

  • medications that stimulate YOUR pancreas to produce insulin, i.e. technically known as
  • Sulfonylurea's:Glypizide(Glucotrol®GlucotrolXL®,Glyberide,(Micronanse®,Diabeta®,Glynase®) and Glimeperide(Amaryrl®), (some generic/ trade names), they targeted the pancreas and can increase the risk for a hypoglycemia
  • medications to suppress/reduce the release of glucose from the liver and stimulate glucose uptake in sensitive tissues at muscle and fat cell areas: i.e. Metformin, (Glucophage, ®, Glucophage® XR, Glumetza™, and Fortamet®)the liver normally releases glucose during the AM hours of 2-4AM)
  • some will slow the digestive process to absorb complex carbohydrates, i.e. or Acarbose (Precose®), Miglitol (Glyset®)
  • some others target the liver, muscles and fat cells to enhance glucose uptake such as: Pioglitazone (Actos®), or Rosiglitazone (Avandia®)
  • new are medications that target incretin hormones, these medications: Or sitagliptin phosphate (Jauvia®) inactivates incretin hormones which play a part in the body’s regulation of glucose. There are 2 major incretin hormones: GLP-1 and GIP (very long names). These GI-derived hormones are released in response to food in the gut. Incretins are responsible for the 'majority' of glucose stimulated insulin secretion. Sitagliptin inhibitors, (Januvia®) will enhance incretin’s action by increasing GLP-1 and GIP. This leads to reduced fasting, postprandial-after meals blood glucose and A1C levels, improved insulin sensitivity and preservation of beta-cell function. However, medications like Januvia® do not slow gastric emptying or cause weight loss/gain or hypo responses.
    Regards Sue
    • Answered By: Susan Throop
    Accreditations: RD, CDE, MA
    Sources Show

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