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The Question
11/15/09 09:45 AM

"What are some, if any of the differences I may encounter if I was to switch from Humalog to Novolog in my insulin pump? thanks"
Asked By:  
Category: Insulin

Background Info Hide
I ask because I am facing higher medical costs this year (work is changing insurance). My friend uses Novolog in her pump; I have always used Humalog-- I hear Novolog is cheaper. My ONLY hesitation lies with the timing because I have (pretty well managed) gastroparesis - and I have to carefully time boluses according to what I have eaten. In some of the research I did, I noticed that Novolog has a faster conversion time versus Humalog and not sure if this is even worth it - although if Novolog is cheaper, I may have to just do it - I will be paying full retail price for my insulin up until 1,500!! many thanks in advance

Expert Answers (1)

11/21/09 03:24 PM

Hello
You present a very good question. Both Novalog and Humalog are rapid acting analog insulins that mimic meal-stumulated insulin secretion when given as a bolus via insulin pump.

Humalog (insulin Lispro) is a rapid acting analog insulin that has an onset of 15 minutes, a peak of action of 1/2 hour to 1 and a 1/2 hours and duration of 6-8 hours.

Novalog (insulin Aspart) is a rapid acting insulin that has an onset of 10 minutes, a peak of 1-3 hours, and duration of 3-5 hours.

All insulins have additives that vary by manufacturer to retard spoilage. These additives can cause allergic reactions in some people.

I suggest you call your insurance carrier to determine which if these rapid acting insulins is on the formulary. Then carefully adjust to which ever insulin they will cover. Look for differences in timing. It will be a trial and error if you have to make a change. Gastroparesis slows digestion so both rapid acting insulins suggest giving the insulin at or after the meal instead of before to get good timing as your digestion needs the action to peak at the time when it will best help you. Be aware of any allergic responses such as rash, or itching.

If you find that because of your insurance carrier's formulary, you must change from one rapid acting insulin to another, then develop an allergic reaction to the new insulin, have your doctor submit a letter of medical necessity to the company describing the reaction. They will most likely agree to cover the previously prescribed insulin because allergies prevent you from changing. The insurance carriers want you to have a safe and effective insulin even if it costs them more.

Please communicate with other type one diabetics in our community on dLife. I think you will find that some people prefer Novalog and some people prefer Humalog. I think it depends on what you are used to and that most of the time you can change without incident.

Answered By: Rita Juray
Accreditations: RN, MLT-ASCP, CCM, CDE
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*** All information contained on dLife.com is intended for informational and educational purposes only. Our Expert Q&A is not intended to be a replacement or substitute for consultation with a qualified medical professional or for professional medical advice related to diabetes or another medical condition. Please contact your physician or medical professional with any questions and concerns about your medical condition.

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