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Is Metformin bad for
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10/27/09 01:31 PM

"Is Metformin bad for your kidneys?"
Asked By: vjenkins2  
Category: Kidney Disease

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I have type 2 diabetes. I take Metformin twice a day and Lantus at night. Just recently found out that 1 of my kidneys is only working 3%.

Expert Answers (1)

11/01/09 02:55 PM

Hello VJenkins2: One of the key precautions for Metformin and kidney function involves the use of iodinated contrast media used in an out-patient procedure or hospitalized surgical procedure. Methformin should be stopped the day of the procedure, and can be restarted 48 hours after renal function has been confirmed to be adequate and stable. Your PCP and other healthcare staffs are VERY aware of these precautions.

Metformin is metabolized by the kidneys, further emphasizing the need for very good blood flow and proper elimination. Metformin/Glucophage, classified as biguanides, target the liver as to suppress glucose production and decrease insulin resistance in the body. The use of metformin is not recommended for renal disease, or a serum creatinine is greater than or equal to 1.5mg/dl for men and greater than or equal to 1.4mg/dl in women, or any abnormal creatinine clearance, (kidney function lab results). It is also not recommended for those with congestive heart failure, have a history of alcohol abuse, or sudden onset or frequent episodes of metabolic acidosis. A referral to a Nephrologist may help reassure its continued/discontinued use.

Maintaining glycemic control is a primary goal and a determinant in achieving positive health outcomes, especially observing behaviors to maintain healthy kidney functions. The ABC's of Diabetes be your best: A1C<7%, Blood pressure<130/80, Total cholesterol<200, HDL>50 in women and >40 for men, LDL<100mg/dl. Thanks for asking dLife. Regards Sue

Answered By: Susan Throop
Accreditations: RD, CDE, MA
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