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Giimepiride 2mg taken
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10/20/09 02:01 PM

"Giimepiride 2mg taken 3 times daily (1 @ breakfast, 1 @ dinner, 2 @ bedtime--max dose,same diet) yield wide a.m.readings: near 100, near 200, etc."
Asked By: jwgreenman  
Category: Blood Glucose Monitoring

Background Info Hide
When metformin lost effectiveness after 4 yrs, I was prescribed Glimepiride with it.. Have huge dawn effect. 2 Glim. at bedtime helps, but results very uneven, even with same diet: some a.m. readings near 100, some near 200. Is Glimepiride inconsistent?

Expert Answers (1)

10/21/09 10:14 AM

Hello JWGreenman: As you indicate, medications can have a mind of their own and it is your 'individual' metabolism that dictates actions and responses. Glyburide, a medication that acts to increase insulin secretion, as to stimulate those beta cells on the pancreas. Glyburide, as you indicate should be taken before meals, has a risk of causing a hypoglycemic reaction, and should not be taken if you have a sulfa allergy. Hypoglycemia is defined as a reading <70mg/dl, however, can occur if the readings have been inconsistent and you have a sudden shift downward.

Diabetes, being defined as a progressive disease, suggesting the production of the insulin,( a hormone), from your pancreas becomes less and less.

Factors to consider that impact your readings:

  • have you changed an activity plan or exercise plan
  • is it an infections or a slight cold, illness, injury, stressed, surgery, (all will impact the readings)
  • activities that are higher intensity, activities that require a great deal of concentration will require more 'fuel'-glucose
  • is some extra carb sneaking into the meal(?)
    Record keeping may help, looking at the factors that affect the blood sugar reading, (stressors, activities, diet and medications). Although labor intensive, monitoring (check 2-4 times per day, vary the times) and logging, date/times, dietary analysis, (www.fitday.com). Have you checked a 2 hour post-meal blood glucose reading, this most closely correlated to the A1c results at the 3 month check. Alternating days and times of testing throughout the day may provide a more complete glucose pattern.

    Hope this helps, continue to be your best: ADA's ABC's

  • A1c<7%
  • Blood Pressure<130/80mmHg
  • Total cholesterol<200,HDL>40
  • LDL<100mg/dl. Thanks for asking dLife, regards Sue
    • Answered By: Susan Throop
    Accreditations: RD, CDE, MA
    Sources Show

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