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The Question
09/18/09 12:43 PM

"I seem to have a delayed reaction to humalog, apidra, and novolog. 2.5 hours later my bl.sugs are still high, but 3hrs later they are normal. Why?"
Asked By: saralottie  
Category: Type 1

Background Info Hide
I've been diabetic for over 50 years. I count carbs, weigh my food and use topump until last month when my blood sugars went so high that I was using over 100 units/day. Previous to that I was using about 40 untis/day. I had small amount of ketones. The docotr's office asked me to go to the hospital ER which I did, but they couldn't help me and let me go home. Since then I went to the doctor's office and they got me on shots (haven't done that in 12 years and am still taking shots of lantus (7@ 6am and 7 @ 6pm) plus 1 unit /5 g. of carb. I eat the same for breakfast and lunch. Dinner varies but is usually 50-100 g of carbs. I also have a snack bef. bed. I test myself just bef. a meal, 2.5 hours after, and bef. bed. My a1c's are high. and at various times of the day my blood sugar gets over 250mg/dcl. I never had high creatnine levels, no other complications and am thankful for being alive, but am frustrated because I don't feel well when my blood sugars are high or low.

Expert Answers (1)

09/27/09 07:44 PM

Saralottie-

Interesting question. All three of these rapid acting insulins potentially can last up to 3 hours. SInce you have had diabetes for a long time it is possible that you have a bit of gastroparesis or slower emptying of foods from your stomach and in turn, a slower pick up of the glucose from your carbs after your meal. Having the reduction at 3 hours is fine, but you might consider a bit experimenting with reducing the amount of fiber in the total meal so the food is digested a bit easier. This may help with it going thru the digestive tract and in turn being picked up by insulin.

If you glucose levels are high during the day at various times do you have variable setting on your pump at different times of the day? I would chat with your pump company CDE and try to have a continuous monitor placed for 3 days, look at your variable levels and make appropriate adjustments.

Be proactive and continue on your search for the best control.

Answered By: Janet HowardDucsay
Accreditations: RN BSN CDE
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Community Answers (2)

12/06/09 07:06 PM

I have had this same problem. More so with Apidra than humalog or novolog though. You may want to try taking your meal bolus a little early. Maybe try 30 minutes before you eat. Do you take more insulin than you used to? You may want to ask your doctor about insulin resistance. My doctor told me that after many years of type one diabetes, it is common for our bodies to start producing antibodies to the insulin we inject. We concequently have to take more insulin which can also lead to weight gain.
Answered By: cc_racer
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09/29/09 05:12 PM

I for got to add that I was tested for gastroparesis and don't have that problem. My stomach emptying is faster than normal.
Answered By: saralottie
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