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The Question
09/12/09 10:15 AM

"What is the causal chain in type 2 diabetes(health-end stage diabetes)?"
Asked By: drone4  
Category: Type 2

Background Info Hide
I work now in a diabetes type 2 project. In my opinion its something like this: health(genetic factors,lifestyle)-obesity(lack of physical activity,bad eating habits)-hypertension-ifg-igt-diabetes. I think hypertension is not in the causal chain...

Expert Answers (1)

10/08/09 08:27 PM

Dear drone4,

Thank you for writing dLife.

It sounds as if you're referring to the "Natural History of Type 2 Diabetes: Disease Progression."

Hypertension does not cause diabetes, however it may be part of the metabolic syndrome which increases ones risk for type 2 diabetes.

Genetic susceptibility and environmental factors (nutrition, obesity and physical inactivity) set the stage for impaired glucose tolerance (IGT). Insulin resistance, hyperinsulinema, low HDL cholesterol and high triglycerides are evidenced as a result of IGT.

Ongoing hyperglycemia leads to the onset of type 2 diabetes, at which time atherosclerosis and hypertension may develop. Of course the ongoing hyperglycemia will lead to the long term complications of diabetes, disability and death.

Answered By: Constance Brown-Riggs
Accreditations: MSEd, RD, CDE, CDN
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