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The Question
10/24/08 05:02 PM

"type 2 diabetic, lost over 40 lbs, waistline went down, but I have such an appetite, insatiable, lol. but i walk a couple of miles a day what's wrong?"
Asked By: tooswt24get  
Category: Food and Nutrition

Background Info Hide
just want to know what am i doing wrong? I don't eat junk food, have an aversion to them. just a lot of salads and baked and boil all foods. do not drink or smoke and am 52 yrs. old and on top of that have a very high sexual craving, it sounds crazy, but this is driving me crazy. please tell me if all this is tied to my diabetes?

Expert Answers (1)

10/27/08 09:31 AM

There is good reason for your insatiable appetite, as Type 2 Diabetes involves a dysregulation of more hormones than insulin. A naturally occurring hormone of your body, called GLP-1, is produced in the intestines of healthy individuals, who do not have diabetes, during the digestion of food. This hormone, as well as others which are only now being identified, stimulate pancreatic beta cells to produce insulin in response to food, while decreasing liver output of glucose during the post meal period. They also slow and regulate the emptying of your stomach, so you have a feeling of fullness or satiety as your stomach fills. A deficiency of the GLP-1 hormone is like trying to fill a bucket with water that has a hole in the bottom. . . It never quite fills, so you lack the experience of feeling full and satisfied after a meal. Byetta is a newer medication for treatment of diabetes which mimics the effect of this naturally occurring GLP-1 hormone in your body, and is a synthetic production of a hormone found in the gut of Gila monsters. . . A lizard which is able to go for extended periods of time without eating due to its extremely slow digestion of food. Another GLP-1 analog which has been developed by NovoNordisk, is longer acting than Byetta, and may more closely resemble your bodies GLP-1. Their drug, called Liraglutide, has been submitted to the FDA for final approval, and should be available latter this year. Yet another drug which works to increase the amount of GLP-1 available to the body by inhibiting the activity of DPP-IV enzymes which break down GLP-1, is called Januvia, and has the advantage of being an oral medication rather than an injection. Januvia, however, may not have as significant an impact on satiety and blood glucose regulation as the GLP-1 analogs. Synthetic GLP-1 and DPP-IV inhibitors have an added advantage, in treatment of diabetes, of decreasing blood glucose excursions (highs and lows) by decreasing the spike in blood glucose following meals, thus helping your pancreas respond to rising levels of blood glucose with increased insulin production, in a manner which helps preserve beta cell function. Concerns as to the incidence of Pancreatitis in a few people who have used Byetta, should be discussed with your Doctor, as monitoring of pancreatic and liver function is most always necessary for people using currently available medications for treatment of Type 2 Diabetes.
Answered By: Claire Blum
Accreditations: MS Ed, RN, CDE, CPT
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Community Answers (1)

11/08/08 01:23 PM

I do not have any answers but am curious to find out if any of this is diabetes related or just plain part of each individuals unique being human, we are so complex it is not even funny, there are so many factors involved in how we think , feel, and beleive, ugh! I feel your pain!
Answered By: deemartin
FLAG
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*** All information contained on dLife.com is intended for informational and educational purposes only. Our Expert Q&A is not intended to be a replacement or substitute for consultation with a qualified medical professional or for professional medical advice related to diabetes or another medical condition. Please contact your physician or medical professional with any questions and concerns about your medical condition.

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