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Archive - 12 - 2013

Dementia Risk Higher in Older Native American, Black Patients with Diabetes

Posted by dlife on Fri, Dec 27, 13, 10:26 AM 0 Comment

December 27, 2013 (Healio) - Older Native American and black patients with type 2 diabetes have an increased risk for developing dementia, according to study results published in Diabetes Care. Researchers surveyed 22,171 patients with diabetes who were aged at least 60 years (66% non-Hispanic white, 11% black, 11% Hispanic, 10% Asian and 2% Native American). The mean age at dementia diagnosis was 79.2 years. During a 10-year follow-up, 17.1% of participants were diagnosed with dementia. Of those, 17.8% were diagnosed with Alzheimer's disease, 12.5% had vascular dementia and 3.4% had Alzheimer's disease and vascular dementia. Researchers found dementia risk was higher among Native Americans and blacks in comparison to other racial groups. Asians had the lowest risk for dementia. Adjusting for BMI and hypertension did not change the correlation between race and risk for dementia. "Among older type 2 diabetes patients, African American and Native American patients are at higher risk of dementia compared with other racial/ethnic groups, and Asian patients are at lower risk of dementia. Somewhat surprisingly, the observed differences were not explained by socio-demographic characteristics or differences in diabetes duration, markers of clinical control, or microvascular or macrovascular complications of diabetes," study researcher Elizabeth R. Mayeda, PhD, MPH, of the University of California, San Francisco, and colleagues concluded. "Given the epidemic of type 2 diabetes and its association with increased risk of dementia, more work is needed to identify factors that may explain these differences in dementia incidence, and ways to eliminate them." Disclosure: The researchers report no relevant financial disclosures

Novel Method Developed for Estimating Insulin Sensitivity

Posted by dlife on Thu, Dec 26, 13, 01:46 PM 0 Comment

December 26, 2013 (Healio) - Researchers from Italy have developed a novel method for estimating insulin sensitivity in patients with type 1 diabetes on sensor-augmented insulin pump therapy, according to data. Minimally invasive continuous glucose monitoring (CGM) devices can measure interstitial glucose concentrations in continuous time for up to several days, according to Michele Schiavon, of the department of information engineering at the University of Padova in Italy, and colleagues. "Insulin sensitivity is an important element in the daily life of patients with type 1 diabetes and could be useful to optimize insulin therapy," researchers wrote. They studied 12 patients with type 1 diabetes who wore both subcutaneous insulin pumps and CGM and found that insulin sensitivity was a key parameter of the metabolic status of a patient. This also could be beneficial for improving insulin therapy in patients with type 1 diabetes, researchers wrote. By using a simple algebraic formulation for each meal, consisting of CGM pump and insulin pump data, they found that the new index of insulin sensitivity was correlated with the oral minimal model (P<10-8). The diurnal pattern also was similar to the oral minimal model, researchers said. "Future studies involving larger databases that include larger cohorts of subjects studied for a longer time are needed to better define the applicability in free living conditions," researchers wrote. Disclosure: The researchers report no relevant financial disclosures.

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