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Archive - 08 - 2007

Treating Diabetes During Pregnancy can Break Link to Childhood Obesity

Posted by dlife on Tue, Aug 28, 07, 11:50 AM 0 Comment

New study shows higher maternal sugar levels increases risk of childhood obesityAugust 28, 2007 (EurekAlert) -- Treating diabetes during pregnancy can break the link between gestational diabetes and childhood obesity, according to a Kaiser Permanente study featured in the September issue of Diabetes Care.The largest study of its kind, this research shows that the risk of childhood obesity rises in tandem with a pregnant womans blood sugar level and that untreated gestational diabetes nearly doubles a child's risk of becoming obese by age 5 to 7. The study also shows for the first time that by treating women with gestational diabetes, the childs risk of becoming obese is significantly reduced. In fact, children whose moms were treated for gestational diabetes had the same risk for becoming obese as children whose mothers had normal blood sugar levels.Researchers at Kaiser Permanentes Center for Health Research (CHR) in Portland and Hawaii used the organizations integrated databases to analyze medical records of 9,439 mother-child pairs. The subjects were members of the health plan in Oregon, Washington and Hawaii and gave birth between 1995 and 2000. The authors found that treating gestational diabetes lowers the child's risk of becoming obese during childhood to the same levels of those pregnant mothers with normal blood sugar levels.Gestational diabetes, the condition in which pregnancy triggers insulin resistance and raises the womans blood glucose level (hyperglycemia), affects up to 8 percent of pregnant women each year in the United States. The rate of childhood obesity in this country more than doubled in the last two decades, so much so that it is now one the nations fastest growing health conditions. Nearly 7 million overweight and obese children in the United States today will grow up to become overweight or obese adults."Hyperglycemia during pregnancy is clearly playing a role in America's epidemic of childhood obesity," said Teresa Hillier, MD, MS, an endocrinologist and senior investigator at CHR Northwest and Hawaii, and the lead author of the study. "The key finding here is that the risk of overweight and obese children rises in step with higher levels of blood sugar during pregnancy. The good news for pregnant women is that by treating gestational diabetes, your children's risk of becoming overweight or obese drops considerably.""My advice to pregnant women is three-fold: Discuss gestational diabetes screening with your doctor, usually between weeks 24 and 28 of pregnancy; if you have gestational diabetes, work with your physician to treat it, and stick with the treatment during your pregnancy. It's the best thing you can do to reduce your child's risk of obesity," said Dr. Hillier.Funded by a grant from the American Diabetes Association, the study was made possible by Kaiser Permanente's interlinked, computerized databases. As the nation's largest and oldest integrated care delivery system, Kaiser Permanente researchers can anonymously review patient records dating back many years and look for connections with the patient's family members and other aspects of the members health.The women in the study were screened during pregnancy for blood sugar level and gestational diabetes. The women's children were measured for weight between the ages of 5 and 7 the so-called "adiposity rebound" period, a strong predictor of adult obesity. The relationship between maternal blood sugar and childhood obesity was then analyzed.Children of mothers with high levels of blood sugar who were untreated were 89 percent more likely to be overweight and 82 percent more likely to be obese by the time they were 5 to 7 years of age, compared to children whose mothers had normal blood sugar levels during pregnancy.The obesity risk of children whose mothers had the highest blood sugar levelsand were treated for gestational diabeteswas not statistically different than children of mothers with normal blood sugar levels. This suggests that the 'metabolic imprinting' for childhood obesity that results from gestational diabetes in pregnant women may be reversible," Hillier said.

UIC Studies Aspirin-Like Treatment for Type 2 Diabetes

Posted by dlife on Mon, Aug 27, 07, 05:24 PM 0 Comment

August 27, 2007 (Newswise) The University of Illinois at Chicago is one of 16 sites in the United States taking part in the first large-scale study to test a promising approach to lowering blood glucose levels in adults with type 2 diabetes.The clinical trial will investigate whether a common anti-inflammatory drug known as salsalate, used to manage arthritis pain, can reduce blood glucose levels in people with type 2, or adult onset, diabetes. The study is funded by the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health.Nearly 21 million people in the United States have diabetes. Type 2 diabetes accounts for about 90 percent to 95 percent of diagnosed cases and is closely linked to obesity, cardiovascular disease, blindness, kidney disease and amputations. People with type 2 diabetes die at rates two to four times higher than those who do not have diabetes.Recent research suggests that chronic inflammation may be involved in the development of insulin resistance and type 2 diabetes, says Theodore Mazzone, professor of medicine at UIC and principal investigator of the clinical trial at that site."By targeting the underlying cause, we hope to determine if reducing inflammation, and thereby lowering blood glucose levels, is a safe and cost-effective treatment for diabetes," Mazzone said. "If this drug treatment is successful, we may also be able to reduce a person's risk of developing associated health problems, such as elevated cholesterol levels and coronary artery disease."Salsalate is chemically similar to aspirin and has been used for more than 40 years to treat pain associated with arthritis, according to the researchers. About 800 adults with poorly controlled blood glucose levels are being sought to participate in the three-year, multi-center study.Researchers are seeking adults ages 18 to 75 whose glucose levels are not well controlled and who do not take insulin. Eligible participants may use no medication or take up to two oral medications to control their diabetes.During the study, participants will be randomized to receive either salsalate or a placebo and will receive all medication and treatments related to the study free of charge. Participants will also be compensated for time and travel. For more information about the study, call Felecia Gilet at (312) 355-4442.For more information about UIC, visit http://www.uic.edu

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