In most people with diabetes, lows occur either because we've overcalculated the amount of insulin we need, or because of an impaired, inhibited, or insufficient glycogen response. While this is obviously an oversimplification, I remember reading that either autoimmunity or modern insulins did weird things to the glycogen response in people with type 1 diabetes, and I know that at least one class of oral diabetes drugs works by inhibiting, if not completely blocking, that response. Then there's the issue of undereating, or not eating sufficiently, for there to be glycogen stores that can be easily converted to fuel our bodies — and, of course, drugs such as glipizide which work by stimulating additional insulin release.






