I'm always high on a site-change day. I've tried doubling the recommended amount of fixed prime, but I still wind up in the upper 200s. I've tried doubling my fixed prime and overbolusing for breakfast (I typically change my site first thing in the morning before breakfast) and I'm still high.

It occurred to me recently that I didn't know for sure if the "trauma" to my body from the site change was the culprit or if it was the insulin absorbing into a new place or both that was to blame. Because I'm only high after breakfast; back into range by lunch time.

Rather by accident, several weeks ago on a Sunday I changed my site and then didn't eat anything for about an hour. I had checked my sugar prior to changing my site and was in a good place. Since I hadn't eaten, I checked again about an hour later and I was sitting in the same spot; I had flatlined! So I was starting to think that it wasn't the act of changing the site that was the problem. My suspicion was confirmed when I checked in at 77 two hours after eating. Or so I thought. It wasn't long after the 77 that I was feeling wickedly low. So low that I treated and then fell asleep. And then Aunt Flo showed up. My experiment was tainted.

I had the chance to test my theory again one day last week. I was running late, so I decided to pick breakfast up on the way in to work. Having tried a new site two days ago that was doing nothing but leaving me constantly in the 200s, I changed my site a day early. I checked my sugar, changed my site and reservoir and got on the road to work (yes, I went back to the mid-belly so I could start seeing some better numbers). After a quick stop at the convenience store, I settled in at my desk and checked my sugar again.

I had jumped nearly 100 mg/dL in an hour without having eaten anything. The only difference was the site change. New suspicion confirmed. 

I will still have to do some experimenting with this to try to decipher what's going on.

Anyone else go through this? Any advice?