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January 9th, 2009
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The title reads "Cancer drugs halt type 1 diabetes in mice." My first response is: oh my gosh! How can this be??!??!! Then I read further. I can feel the emotions starting to get the best of me.

 

Do I break out in song? Do I start dancing around the room? Do I cry? What if this is it? What if this breakthrough is the one that we all have been striving for?

 

The article explains that research has shown two cancer drugs, Gleevec and Sutent, to halt type 1 diabetes occurrence in mice. It also says that up to 80 percent of the mice with type 1 diabetes went into remission from the drug. Eighty percent!

 

Gleevec is used to fight a specific chromosomal leukemia. Minor side effects are listed, such as nausea, skin blisters, and fluid retention. However, there are more severe side effects listed like liver problems, heart failure, and abnormal bleeding. A very strong caution is listed for women who may become pregnant or who are breast-feeding as Gleevec can cause harm to the fetus or child.

 

Sutent is used to fight renal cell carcinoma and gastrointestinal tumors. It also includes the normal minor side effects, such as nausea, vomiting, fatigue, etc. The more serious side effects to Sutent are heart problems, bowel wall perforation, kidney disorders, and increased blood pressure.

 

Both of these drugs have potential hazards when combined with specific drugs. For instance, Gleevec should not be used alongside certain antibiotics, antidepressants, or cholesterol lowering medications. Sutent does not mention any specific drugs to avoid combining with its treatment.

 

It's amazing to me that it could take only two pills to be rid of diabetes. No more pumps, no more meters, no more lows or highs. Yet, it also amazes me that the side effects and complications of these medications are some of the complications that I fight so hard to avoid. And the combination of some pills that diabetics are so often on may prevent a cure from being easily accessible.

 

Would taking these medications be worth the risk of diabetes in general? How long might it take to know if long term remission is possible? Would I want to wait to begin this treatment until after I have kids? Or do I want to take the medication now and adopt to avoid any complications?

 

It's exciting, frightening, and frustrating to think that a cure might be in two pills and that cure might be a few short years away. I'm still not sure if I should break into song, dance around the room, or just cry.



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After waiting for a cure for the past 20 years, it's still hard not to get excited each time a new lead comes about. Hang in there, keep taking care of yourself and if possible, find out ways to be a part of the research with these leads. I am in the process of working with UCSF after I receive a new kidney next month. I'll be having the islet cell transplant and can hardly wait.

I never thought I'd be able to be involved with a research project but things outside of my power opened the doors to it. Now that I am, I feel like this whole experience is almost worth it.


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Lindsey Guerin
Lindsey is a typical, yet unique, Texas girl who loves shopping, movies and reading. She loves to travel and take risks. She dreams of diabetes cures, never-ending cheesecake and her own airplane. The rest you can discover in her blog!(Read More)

Latest Posts: Medication Station | Doctor, Doctor... | My Nine for 09

Scott Marvel
Scott lives an active life with type 1 diabetes. Aiming to stay on top of his unexpected diagnosis, he puts a strong foot forward to stay in control.
Living life in the sun and fulfilling his dreams, Scott tries to educate himself, and others, on the unquestionable possibilities of a life with type 1 diabetes.(Read More)


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