Other SGLT-2s in Development
The recent approval of Invokana is exciting, opening the door to a new class of medications that can help people to manage type 2 diabetes, but it was not exactly the only drug on that long road to approval. Take a look at other potential medications that are in various stages of trials and approvals that may join this newest class of oral medications.
Astellas Pharma – Ipragliflozin
- This drug has been filed for marketing approval in Japan and is in the process of completing phase III trials.
- Trials have shown its potential to significantly lower glycated hemoglobin levels (HbA1c) over time as compared to placebo.
Bi/Lilly – Empagliflozin
- This drug is in Phase III of clinical trial process involving over 14,500 patients. There will be a total of 12 clinical trials performed throughout several countries.
- It is said that the companies will present results of the studies at some point in 2013 or 2014.
Chugai (Roche) – Tofogliflozin Hydrate
- According to Chugai Pharma, as of November 2010, this drug is in Phase III of clinical trials.
Lexicon – LX4211
- This drug inhibits both SGLT1 and SGLT2, making it the first of its kind to be introduced in clinical development for diabetes.
- LX4211 will begin Phase III clinical studies in the middle of 2013.
Taisho Pharma – luseogliflozin
- This drug is currently in Phase III of clinical trials.
Bristol-Myers Squibb – Farxiga
- This is a once- daily oral treatment specifically geared toward type 2 diabetes, to be used in conjunction with exercise and a proper diet. This treatment is currently in clinical trials.
Reviewed by James A. Bennett 04/14.
- • Astellas. AVEO and Astellas announce postive findings from TIVO-1 superiority study of tivozanib in first line advanced RCC., http://www.astellas.com/en/corporate/news/pdf/121003_Eg_1.pdf. (PDF) (Accessed 4/11/13.)
- • Lexicon Pharmaceuticals. LX4211, http://www.lexgen.com/pipeline/lx4211.html. (Accessed 4/11/13.)
- • Chugai Pharma USA. Annual report, 2011. http://www.chugai-pharm.co.jp/hc/ss/downloads/eAR2011_12_09.pdf?blobheader=application%2Fpdf&blobheadername1=content-disposition&blobheadervalue1=inline%3Bfilename%3DeAR2011_12_09.pdf&blobwhere=1259656736395&ssbinary=true. (PDF) (Accessed 4/11/13.)
- • Theheart.org. FDA approves new diabetes drug, canagliflozin, despite CV concerns, http://www.theheart.org/article/1523789.do. (Accessed 4/11/13.)
- • Drug Discovery & Development Magazine. Lilly, BI submit empagliflozin to FDA, http://www.dddmag.com/news/2013/03/lilly-bi-submit-empagliflozin-fda. (Accessed 4/11/13.)
Cabbage Gratin Cheesecake Dipping Sauce with Bananas Beef Suey Corn, Lima Bean, and Cucumber Succotash Turkey and Tomato Casserole Firecracker Barbecue Pork Linguine with Swiss Chard Mandarin Spinach Salad Wonton Fruit Tarts Peanut Poppers
As the thoughts of adoption cross my mind, I have a nagging on my heart that reminds me that I am not alone in this. Not alone in a positive way that I have the support of my husband and I'm building a great medical team to help me tackle any fertility challenges that come along. But not alone in that it's not just my emotions and desires that dictate how, when, or if I have children. Yesterday, I was chatting with a volunteer at work. He and his wife have a two year old and we...