Diabetes News

Archive - 08 - 2014

Risk of Diabetes Up in Hodgkin's Lymphoma Survivors

Posted by dlife on Fri, Aug 29, 14, 12:25 PM 0 Comment

August 29, 2014 (PhysiciansBriefing) - Para-aortic radiation correlates with increased diabetes mellitus (DM) risk for Hodgkin's lymphoma (HL) survivors, according to a study published online Aug. 25 in the Journal of Clinical Oncology. Frederika A. van Nimwegen, from the Netherlands Cancer Institute in Amsterdam, and colleagues examined the correlation between treatment for HL and DM risk in a cohort of 2,264 five-year HL survivors. Participants were diagnosed before age 51 years and received treatment between 1965 and 1995. Medical records and general practitioners provided treatment and follow-up information. The researchers found that 157 patients developed DM after a median follow-up of 21.5 years. After 30 years, the overall cumulative incidence of DM was 8.3 percent. The cumulative incidence of DM was 14.2 percent after para-aortic radiation with =36 Gy. The risk of DM was increased 2.30-fold with irradiation with =36 Gy to the para-aortic lymph nodes and spleen, while the risk was increased 1.82-fold with para-aortic radiation alone with =36 Gy. The risk of DM was not significantly increased with lower doses (10 to 35 Gy). Higher mean radiation doses to the pancreatic tail correlated with significantly increased risk of DM (P < 0.001). "Screening for DM should be considered in follow-up guidelines for HL survivors, and treating physicians should be alert to this increased risk," the authors write.

Metabolic Health No Guard against Obesity-Related Diabetes

Posted by dlife on Fri, Aug 29, 14, 12:23 PM 0 Comment

August 29, 2014 (MedwireNews) - Research suggests that overweight and obesity per se increase the risk of diabetes in young men, even if they have no metabolic abnormalities or diabetes risk factors. "This finding emphasizes the importance of tight follow-up of overweight and obese young adults for diabetes incidence, independent of the presence of other risk factors", say lead study author Gilad Twig (Sheba Medical Center, Tel Hashomer, Israel) and colleagues. The results are based on a median 6.1 years' follow-up of 33,939 men, aged an average of 30.9 years, in the Metabolic, Lifestyle and Nutrition Assessment in Young Adults cohort. During this time, 734 new cases of diabetes emerged, and each unit increase in participants' body mass index (BMI) was associated with a 10.6% increase in the likelihood of developing diabetes. Metabolically healthy people were defined as those free of any National Cholesterol Education Program?Adult Treatment Panel III metabolic abnormalities, ie, components of the metabolic syndrome. This included 9183 (55%) of 16,668 normal-weight men and 4207 (32%) of 12,996 overweight or obese men. Diabetes incidence rose in line with BMI category and number of baseline metabolic abnormalities, and was significantly higher in obese than normal-weight metabolically healthy men, at 4.34 versus 1.15 cases per 1000 person?years. Indeed, in a multivariate model that included family history of diabetes, metabolically healthy men had a significant 1.60-fold increased risk of diabetes if they were overweight and a 2.74-fold increased risk if they were obese. The team describes this finding as "intriguing", suggesting that "[w]hile obesity seems to mediate the incidence of diabetes, independent of the above-mentioned classic risk factors, it may still be mediated by significant insulin resistance and/or ?-cell dysfunction that have not yet resulted in dysglycemia or dyslipidemia." The addition of baseline metabolic abnormalities increased participants' diabetes risk, with a stronger effect in normal-weight men, at a 67% increase per abnormality, than in obese men, at a 51% increase. Writing in Diabetes Care, Twig et al note that their findings in young men contradict some studies of middle-aged people, in whom metabolically healthy obesity was associated with a low diabetes risk. They suggest this may be "a result of survival bias, as this group consists of men who were likely overweight or obese for many years and nevertheless have not developed diabetes or other metabolic abnormalities."

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